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In general, peptide structure, receptor targets, and downstream signaling together predict if a given peptide will promote or inhibit male reproductive function

B12 injection shots can usually be felt within 24 hours (and a change should show in blood tests after a month or two) A high dose of B12 oral supplementation takes the same time as an injection: roughly 24 hours to feel an improvement and then up to 2 months to show in blood markers

This reaction is catalyzed by the enzyme methionine synthase with B 12 as an essential cofactor